Skip to content

Serum D-Serine Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of D-serine, a naturally occurring amino acid found in your blood serum. D-serine plays a role in brain function and nerve signaling.

Quick summary

["D-serine levels may be checked to help understand certain neurological conditions or as part of broader metabolic evaluations."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
79648-2
Short code
D-serine CSF-sCnc
Synonyms
D-serine CSF-sCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms or conditions linked to abnormal D-serine levels, such as neurological disorders, seizures, or certain metabolic syndromes. It may also be part of research or specialized diagnostic testing for conditions affecting neurotransmission or brain chemistry.

What Does the Result Mean?

D-serine is typically present in small amounts in the blood. Results may be compared to reference ranges provided by your lab, but these can vary by lab. Abnormal results could suggest underlying neurological, metabolic, or other health issues that require further evaluation.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The serum portion is separated and analyzed using a specialized laboratory technique to measure D-serine concentration.

What Are Common Causes of Abnormal Results?

While D-serine is mostly involved in brain function, some conditions or medications that affect neurotransmitter balance—such as certain neurological disorders, epilepsy, or metabolic disorders—might influence its levels. However, individual results depend on many factors, including diet, health status, and lab-specific methods.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

D-Serine in Serum

Frequently asked questions

What factors might affect my D-serine test results?
Several factors could influence your D-serine levels, including recent diet (especially protein intake), hydration status, medications affecting neurotransmitters, and underlying health conditions like kidney or liver disease. If you’re taking medications, discuss them with your provider before testing.
Can diet or supplements affect this test?
Yes, dietary protein and certain supplements (like amino acids) may temporarily alter D-serine levels. Avoid high-protein meals or supplements for 24 hours before testing to get a more accurate result.
Is this test always done in conjunction with other tests?
Sometimes, but not always. Your provider may order it as part of a broader evaluation for neurological, metabolic, or research-related reasons. Results are interpreted alongside clinical findings and other tests if applicable.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy