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Serum/plasma mass concentration of protein (e.g., albumin, globulin, or total protein)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins are essential for transporting nutrients, maintaining fluid balance, and supporting immune function.

Quick summary

["Total protein helps assess overall protein status and identify potential deficiencies or overproduction."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
112048-4
Short code
Dx Mnr ppl Endscpy
Synonyms
Dx Mnr ppl Endscpy
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
endoscopy
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like malnutrition, kidney disease, liver problems, or dehydration. It can also help evaluate protein-losing disorders or monitor treatment responses in certain conditions.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein (usually in your arm) to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Lower-than-expected protein levels might suggest malnutrition, kidney or liver disease, or excessive fluid loss. Higher-than-expected levels could indicate dehydration, multiple myeloma, or other rare conditions. Your provider will interpret results in the context of your health history.

Common Conditions Monitored

This test is often used to monitor conditions like chronic kidney disease, liver cirrhosis, or severe infections where protein levels may drop. It can also help diagnose conditions like nephrotic syndrome or protein-losing enteropathies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Abnormal protein levels can signal underlying health issues, such as organ dysfunction or nutritional deficiencies. Low protein may indicate poor nutrient absorption, while high protein could reflect conditions like dehydration or certain cancers. Regular monitoring helps track disease progression or treatment effectiveness.

Short name

Total Protein (Serum/Plasma)

Frequently asked questions

What causes low protein levels in the blood?
Low protein levels can result from conditions like kidney disease, liver problems, malnutrition, or excessive vomiting/diarrhea. Certain medications or infections may also affect protein production or loss.
What should I do if my protein test results are abnormal?
Follow your healthcare provider’s advice for next steps, which may include dietary changes, further testing, or treatment adjustments. They’ll help determine the cause and recommend appropriate care.
Can diet affect protein test results?
Yes, diet can influence protein levels. High-protein diets may temporarily raise levels, while poor nutrition (e.g., low-calorie intake) can lower them. Avoid extreme dietary changes before retesting unless directed by your provider.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy