Skip to content

Serum or Plasma Bicarbonate Concentration (Metabolic Acidosis/Baseline Electrolyte Profile)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of bicarbonate in your blood, which helps regulate your body’s acid-base balance. It’s often checked alongside other electrolytes to assess conditions like metabolic acidosis or alkalosis.

Quick summary

["Bicarbonate helps balance acidity in your blood and can signal underlying health issues like kidney problems or metabolic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111960-1
Short code
Dx SB Endscpy
Synonyms
Dx SB Endscpy
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
endoscopy
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may order this test if you have symptoms like fatigue, confusion, or shortness of breath, or if they suspect conditions like kidney disease, diabetes, or heart failure. It’s also part of routine monitoring for patients with chronic illnesses or those taking medications that affect acid-base balance.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a fasting profile. Bring any medications you’re currently taking to your appointment.

How the Test Is Performed

A healthcare provider will draw blood from a vein in your arm using a small needle. The blood sample is then sent to a lab for analysis. The test typically takes a few minutes, and you may feel a slight pinch during the draw.

What the Results Mean

Results help determine whether your body’s acid-base balance is normal or if there’s an imbalance (such as too much or too little bicarbonate). Low levels may indicate metabolic acidosis, while high levels could suggest metabolic alkalosis. Your doctor will discuss these findings in relation to your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Bicarbonate Level

Frequently asked questions

What does a low bicarbonate level mean?
A low bicarbonate level often points to metabolic acidosis, which can occur due to conditions like kidney disease, severe dehydration, or certain medications. It may also signal diabetes, liver problems, or respiratory issues. Your doctor will evaluate the results alongside other tests and symptoms to diagnose the underlying cause.
How often should I get this test?
The frequency depends on your health condition. If you have a chronic illness (like kidney disease or diabetes), your doctor may recommend regular monitoring. If this test is part of a routine checkup or for a specific reason (like an illness), follow their guidance on timing.
Can lifestyle changes affect bicarbonate levels?
Yes, certain lifestyle factors may influence bicarbonate levels. For example, dehydration, excessive alcohol use, or certain diets (like very low-carb diets) can temporarily alter results. Always discuss any changes in diet, medications, or symptoms with your healthcare provider before interpreting test results.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy