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Cancer-associated antigen 125 (CA-125) DNA probe assay for ovarian cancer screening

Published: August 9, 2026Updated: August 16, 2026

This test detects a specific genetic marker (CA-125 DNA) associated with ovarian cancer using a molecular probe. It’s part of a screening process to help identify potential risks.

Quick summary

["This test helps assess ovarian cancer risk by detecting a genetic marker in a blood sample."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
93840-7
Short code
EBV DNA Bld NAA+probe-aCnc
Synonyms
EBV DNA Bld NAA+probe-aCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test uses a specialized probe to identify fragments of CA-125 DNA, a protein often linked to ovarian cancer. While not a direct cancer test, it may indicate abnormal cells that warrant further evaluation.

How the Test Works

A small sample of your blood is collected and analyzed using advanced molecular techniques. The probe binds to CA-125 DNA if present, allowing for detection and potential risk assessment.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of ovarian cancer, are at higher risk, or as part of routine screening in certain populations.

Limitations and Considerations

This test is not a definitive cancer diagnosis. False positives or negatives can occur, and results should always be reviewed by a medical professional alongside other tests and clinical findings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

While CA-125 DNA testing is not a standard screening tool for all individuals, it may play a role in targeted screening for those at elevated risk. Early detection can improve outcomes, but it should complement—not replace—other diagnostic methods like imaging and clinical evaluations.

Short name

CA-125 DNA probe

Frequently asked questions

What does a positive result mean?
A positive result suggests the presence of CA-125 DNA, which may indicate abnormal cells. This does not confirm cancer but may prompt further testing, such as ultrasounds or biopsies, to investigate further.
How often should I get this test?
Your healthcare provider will determine the frequency based on your individual risk factors, medical history, and recommendations from guidelines like those from the American Cancer Society or National Comprehensive Cancer Network.
Is this test covered by insurance?
Coverage depends on your insurance plan, medical necessity, and whether you qualify for screening based on risk factors. Always check with your insurance provider or healthcare team for specifics.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy