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Epstein-Barr Virus Nuclear Antigen Antibody, Serum (IgG)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies to Epstein-Barr virus (EBV) in your blood. These antibodies indicate whether your immune system has encountered the virus, which can cause infections like mononucleosis.

Quick summary

["This test helps track past or current EBV exposure and assess immune response."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30138-2
Short code
EBV NA Ab sp2 Ser Ql
Synonyms
EBV NA Ab sp2 Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of EBV infection, such as fever, fatigue, swollen lymph nodes, or sore throat. It may also be used in monitoring for conditions like infectious mononucleosis, lymphoma, or other EBV-related diseases. Additionally, it can be part of a broader evaluation for immune system function or chronic illnesses linked to EBV.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes about 15 minutes. If you’re on blood thinners or have a history of bleeding issues, let your provider know beforehand.

What the Results Mean

Positive results (high antibody levels) suggest past or current EBV infection. Negative results mean the virus may not have been detected in your blood at the time of testing. Levels can vary over time, so repeated testing may be needed for monitoring.

Common Reasons for Testing

This test is often used to diagnose EBV-related illnesses, evaluate immune responses, or screen for conditions like chronic active EBV infection or post-transplant lymphoproliferative disorder (PTLD). It can also help assess exposure in research or epidemiological studies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

EBV IgG Antibody

Frequently asked questions

What does a positive result mean for my health?
A positive result indicates your body has produced antibodies against EBV, meaning you’ve likely had exposure to the virus at some point. This doesn’t necessarily mean you’re currently sick, but it confirms past infection. If you’re symptomatic, your provider may recommend further evaluation to rule out conditions like mononucleosis or other EBV-related complications.
Can this test help diagnose active EBV infection?
While this test confirms past or current EBV exposure, it doesn’t always pinpoint active infection. Your provider may order additional tests, such as viral load or PCR testing, to check for active EBV replication if needed. Symptoms like fever, fatigue, or swollen glands may guide further investigation.
How often should I get this test?
The frequency depends on your clinical situation. If you’re monitoring chronic conditions linked to EBV, your provider may recommend periodic testing. Otherwise, this test is typically done once or as part of a specific evaluation. Follow-up may be needed if results are abnormal or if symptoms persist.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy