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Epstein-Barr Virus Nuclear Antigen Antibody, Total (IgG, IgM, IgA)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies to Epstein-Barr virus (EBV) nuclear antigen, which helps identify past or current infection by the virus. It may be used to diagnose or monitor conditions related to EBV exposure.

Quick summary

["This test helps track EBV exposure and infection status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42498-6
Short code
EBV NA Ab Titr CSF
Synonyms
EBV NA Ab Titr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like fatigue, sore throat, or swollen lymph nodes, which can sometimes be linked to EBV. It may also be used to diagnose conditions such as infectious mononucleosis or to monitor chronic infections in immunocompromised individuals.

What the Test Measures

The test detects antibodies (IgG, IgM, and IgA) against EBV nuclear antigen. IgM antibodies typically appear early in infection and fade over time, while IgG antibodies persist longer, indicating past or ongoing infection.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The sample is processed to separate serum or plasma, which is then tested for the presence of EBV nuclear antigen antibodies using immunoassay methods.

What the Results Mean

Positive results suggest exposure to EBV, with different antibody patterns indicating varying stages of infection. High IgM levels often mean recent infection, while high IgG levels may indicate chronic infection or past exposure.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results can confirm EBV infection, which can cause symptoms like fever, fatigue, and swollen glands. It may also help diagnose conditions like mononucleosis or guide treatment decisions in immunocompromised patients. Always discuss results with your healthcare provider for personalized interpretation.

Short name

EBV Nuclear Antigen Antibody

Frequently asked questions

What does a positive result mean for my health?
A positive result indicates you have been exposed to EBV, which can cause infections like mononucleosis. It does not always mean you are currently sick, but it confirms past or ongoing exposure. Your provider will discuss next steps based on your symptoms and overall health.
Can this test tell me if I have active EBV infection?
This test primarily measures antibodies, which can indicate past or current infection. However, it does not always show active infection directly. Your provider may order additional tests to assess active viral replication if needed.
How long do the antibodies stay in my system after infection?
IgM antibodies typically decrease within months after infection, while IgG antibodies can remain for years. The duration depends on your immune response and overall health. Your provider can help interpret long-term results based on your situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy