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Epstein-Barr Virus (EBV) Nuclear Antigen IgG Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies to the nuclear antigen of Epstein-Barr virus (EBV) in your blood. These antibodies indicate past or current infection by EBV, a common virus that can cause infections like mononucleosis.

Quick summary

["This test helps determine if you’ve been exposed to EBV or if your immune system is still responding to it."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31373-4
Short code
EBV NA IgG CSF-aCnc
Synonyms
EBV NA IgG CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies specific to EBV’s nuclear antigen. IgG antibodies are typically produced after an initial infection and can remain in your system for years, showing long-term immunity or past exposure.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms of EBV infection (e.g., fatigue, sore throat, swollen lymph nodes), if you’ve been exposed to someone with EBV, or if you’re investigating chronic conditions linked to EBV, such as certain cancers or autoimmune diseases.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. The process usually takes a few minutes, and you may feel slight discomfort.

What to Expect After the Test

After the blood draw, you may experience mild bruising or soreness at the site. Apply pressure to the area to help stop bleeding. You can resume normal activities immediately.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results suggest past or current EBV infection. While most people recover fully, some may experience long-term effects or develop complications like chronic fatigue syndrome or certain cancers. This test is not used to diagnose acute EBV infection but can help assess exposure and immune response over time.

Short name

EBV IgG Antibody

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 24 to 72 hours, depending on your lab’s processing schedule. Your healthcare provider will discuss the findings with you during your follow-up visit.
Can I have this test if I’m pregnant?
Yes, this test is generally safe during pregnancy. However, always inform your healthcare provider about any medications or conditions you have before the test to ensure it’s appropriate for your situation.
Does this test differentiate between acute and chronic EBV infection?
No, this test only measures IgG antibodies, which indicate past or current EBV exposure but do not distinguish between acute (short-term) or chronic (long-term) infection. Additional tests may be needed for a full assessment.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy