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Epstein-Barr Virus (EBV) Nuclear Antigen IgG Antibody, Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies to the Epstein-Barr virus (EBV) in your blood. These antibodies develop after infection and can help track past exposure to the virus.

Quick summary

["This test helps determine if you’ve had EBV infection, which can cause conditions like mononucleosis or long-term health effects in some cases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18428-3
Short code
EBV NA IgG CSF Ql
Synonyms
EBV NA IgG CSF Ql
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects **IgG antibodies** specific to the Epstein-Barr virus (EBV). IgG antibodies are typically produced months to years after initial infection and can remain in your blood for a long time. This indicates past exposure to EBV, though it doesn’t always mean you’re currently infected or ill.

Why Might You Need This Test?

Doctors may order this test if you have symptoms of EBV infection (like fatigue, sore throat, or swollen lymph nodes), if you’ve been exposed to someone with EBV, or if you’re being evaluated for conditions linked to EBV, such as certain cancers or autoimmune diseases.

What Does a Positive Result Mean?

A positive result suggests you’ve likely had EBV in the past. However, it doesn’t confirm whether you’re currently infected or experiencing symptoms. If you’re concerned about active infection, your doctor may recommend additional testing.

What Does a Negative Result Mean?

A negative result means your blood sample didn’t show detectable IgG antibodies to EBV at this time. This could mean you’ve never been exposed to EBV or that your body hasn’t yet produced these antibodies (e.g., shortly after infection).

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

EBV IgG Antibody

Frequently asked questions

How Is This Test Done?
A blood sample is taken from a vein in your arm. The sample is sent to a lab, where it’s tested for EBV-specific IgG antibodies using an **immunoassay** method. Results are typically available within 1–3 business days.
What Are Common Causes of False Results?
False negatives are more likely if you’ve recently been infected (within a few months) or if your antibody levels are very low. False positives are rare but can occur if there’s a lab error or if you have an unrelated autoimmune condition that causes similar antibody responses.
Can This Test Be Used to Diagnose Active EBV Infection?
No, this test alone cannot diagnose an active EBV infection. If you suspect recent infection, your doctor may recommend additional tests, such as checking for **EBV viral load** or **EBV capsid antigen IgG antibodies**, which can indicate current viral activity.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy