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Epstein-Barr Virus Nuclear Antigen IgG Antibody (IgG Antibody to EBV Nuclear Antigen)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies to Epstein-Barr Virus (EBV) nuclear antigen in your blood. It helps determine past or current infection with EBV, a common virus that can affect the immune system.

Quick summary

["Assesses past EBV exposure and potential long-term immune response."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16825-2
Short code
EBV NA IgG Fld Ql
Synonyms
EBV NA IgG Fld Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to diagnose or monitor Epstein-Barr Virus (EBV) infection, which can cause conditions like infectious mononucleosis (mono). It can also be used to evaluate immune function or guide treatment for certain autoimmune or lymphoproliferative disorders.

What to Expect Before the Test

No special preparation is needed. A blood sample is drawn from a vein, typically in your arm, by a healthcare professional.

How the Test Works

The test detects IgG antibodies specific to EBV nuclear antigen, indicating an immune response to the virus. These antibodies are produced after initial infection and can persist for years.

Possible Results and Their Meaning

A positive result suggests past or current EBV infection. The exact meaning depends on clinical context, such as symptoms, medical history, or other test results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

EBV IgG Antibody (Nuclear Antigen)

Frequently asked questions

What does a positive result mean for my health?
A positive result indicates you likely had EBV at some point, which is common. It does not necessarily mean you are currently infected, but it confirms your immune system has responded to the virus. Consult your doctor for interpretation based on your symptoms and medical history.
Can this test detect acute EBV infection?
This test primarily detects IgG antibodies, which develop after initial infection. For acute EBV infection, doctors may also order additional tests, such as those for viral capsid antigen (VCA) IgM antibodies, to confirm recent exposure.
Does this test differentiate between different EBV strains?
No, this test measures antibodies to a specific EBV nuclear antigen and does not distinguish between different EBV strains or variants. It provides general information about past exposure to EBV.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy