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Epstein-Barr Virus Nuclear Antigen IgG Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies to Epstein-Barr virus (EBV) in your blood. These antibodies indicate past or ongoing infection with EBV, a common virus that can affect the immune system.

Quick summary

["This test helps determine if you’ve been exposed to EBV or if your immune system is still responding to it."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109901-9
Short code
EBV NA IgG Msmt CSF
Synonyms
EBV NA IgG Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies specific to the Epstein-Barr virus nuclear antigen (EBNA). IgG antibodies are typically produced after an initial infection and can remain in your system for years. This helps doctors assess whether you’ve had EBV exposure and if your immune response is active.

Why Might You Need This Test?

Doctors may order this test if you have symptoms like fatigue, sore throat, or swollen lymph nodes that could be linked to EBV. It can also be used to monitor chronic conditions like infectious mononucleosis or certain cancers (e.g., Burkitt lymphoma) associated with EBV.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The sample is sent to a lab, where antibodies to EBNA are measured using an immunoassay method. Results are reported as positive or negative, or sometimes as a quantitative value indicating antibody levels.

What Are the Possible Results?

A positive result means you likely have developed IgG antibodies to EBV, suggesting past infection. A negative result may mean you’ve never been exposed or the test was taken too early after exposure. Quantitative results can help track antibody levels over time.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is crucial for diagnosing EBV-related conditions, such as infectious mononucleosis, or assessing immune responses in patients with EBV-associated cancers. It can also help rule out other conditions with similar symptoms. High antibody levels may indicate chronic infection, while low levels suggest recent or no exposure.

Short name

EBV IgG Antibody

Frequently asked questions

What does a positive result mean?
A positive result means your body has produced antibodies against EBV, indicating you’ve likely had an infection at some point. This doesn’t necessarily mean you’re currently sick, but it confirms past exposure. Your immune system may still be responding to the virus.
Can this test detect active EBV infection?
This test primarily detects IgG antibodies, which develop after an initial infection. While it can indicate past exposure, it doesn’t directly measure active infection. For active EBV infection, other tests (like viral capsid antibody or viral load) may be used.
How long after infection might I get a positive result?
IgG antibodies typically appear within weeks to months after an EBV infection. Some people may have detectable levels for years. If you suspect recent exposure, your doctor may recommend retesting after a few weeks to monitor antibody development.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy