Epstein-Barr Virus Nuclear Antigen IgG Antibody (Serum)

Why This Test Matters

EBV is a well-known virus that can affect your immune system. After an initial infection, your body produces antibodies, including IgG antibodies, to fight it off. This test checks for these antibodies to determine if you’ve been exposed to EBV in the past. High levels may indicate chronic infection or reactivation, especially in conditions like infectious mononucleosis or certain cancers.

What to Expect During Testing

A small blood sample is drawn from a vein in your arm. The sample is sent to a lab where it’s tested for EBV IgG antibodies using an immunoassay method. Results are typically available within a few days. No special preparation is needed, but fasting may not be required unless instructed by your healthcare provider.

Common Uses for This Test

Doctors may order this test to diagnose or monitor conditions linked to EBV, such as chronic fatigue syndrome, certain lymphomas, or to confirm past infection after symptoms have resolved. It can also help assess immune function in people with weakened immune systems.

What the Results Mean

Positive results (detecting EBV IgG antibodies) suggest you’ve had an EBV infection at some point. The presence of these antibodies doesn’t indicate whether you’re currently infected or if the virus is active. Your doctor will interpret results in the context of your symptoms and medical history.