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Epstein-Barr Virus Nuclear Antigen IgG Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures your body’s immune response to the Epstein-Barr virus (EBV), a common virus that can cause infections like mononucleosis. It helps determine if you’ve been exposed to EBV and whether your immune system has developed antibodies against it.

Quick summary

["This test helps track past infection and immune response to EBV."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5156-5
Short code
EBV NA IgG Ser Ql IA
Synonyms
EBV NA IgG Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies specific to the nuclear antigen of Epstein-Barr virus (EBV). IgG antibodies are part of your immune system’s long-term defense and appear after an initial infection has resolved. This test is used to confirm past exposure to EBV rather than an active infection.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have symptoms suggestive of EBV infection (e.g., fatigue, fever, swollen lymph nodes) or if you’re being evaluated for conditions linked to EBV, such as certain cancers or autoimmune diseases.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The serum portion is separated and tested for EBV-specific IgG antibodies using an immunoassay method, which identifies the presence of these antibodies in your blood.

What Are the Results Typically Used For?

Positive results indicate you’ve likely had an EBV infection at some point in your life. However, a positive test alone doesn’t confirm an active infection—it only shows prior exposure. Results are used to guide further evaluation if needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

EBV IgG Antibody (Serum)

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 1 to 3 business days, depending on lab processing times. Your healthcare provider will discuss the findings with you during your follow-up visit.
Can a positive EBV IgG test mean I have an active infection?
No, a positive EBV IgG test indicates past exposure but does not confirm an active infection. Active EBV infection is usually diagnosed through other tests, such as viral load or acute-phase antibodies.
Is this test sensitive to recent or recent-onset EBV infection?
This test is most useful for detecting long-term immune response. Acute or recent EBV infections may require additional testing to confirm, as IgG antibodies may take weeks to develop after exposure.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy