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Epstein-Barr Virus Nuclear Antigen IgG Antibody (IgG Antibody to EBV Nuclear Antigen)

Published: August 9, 2026Updated: August 16, 2026

This blood test checks for antibodies to Epstein-Barr virus (EBV), a common virus that can cause infections like mononucleosis.

Quick summary

["This test helps determine past or current infection by EBV and may guide treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22298-4
Short code
EBV NA IgG Titr Ser
Synonyms
EBV NA IgG Titr Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82977
SNOMED
3110003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms of EBV infection, such as fever, fatigue, swollen lymph nodes, or sore throat. It can also be used to diagnose conditions like infectious mononucleosis or to monitor chronic infections in certain cases.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. Tell your healthcare provider if you have a blood clotting disorder or are on blood thinners.

What the Test Results Mean

Positive results indicate the presence of IgG antibodies, suggesting you have had EBV infection at some point. These antibodies remain in your blood for life after recovery. If results are negative, it means you likely haven’t been exposed to EBV recently.

Common Conditions Linked to This Test

This test is often used to diagnose or confirm EBV-related illnesses, such as mononucleosis, or to assess immune responses in conditions like chronic fatigue syndrome or certain cancers linked to EBV.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Elevated IgG levels are diagnostic for past EBV infection. While IgG antibodies alone don’t indicate active infection, they are critical for identifying exposure history. In clinical practice, this test is often used alongside clinical symptoms and other diagnostic criteria to guide diagnosis and management of EBV-related conditions.

Short name

EBV IgG Antibody

Frequently asked questions

What does a positive result mean?
A positive result means your body has produced antibodies to EBV, indicating you’ve likely had an infection at some point. These antibodies stay in your system long-term and can help your doctor confirm past exposure, especially if you’re experiencing symptoms or investigating conditions linked to EBV.
Can this test detect active EBV infection?
This test primarily detects IgG antibodies, which develop after an active EBV infection has resolved. For detecting active infection, other tests or clinical evaluation may be needed, such as measuring viral loads or checking for acute-phase antibodies.
Is there any risk or discomfort with this blood test?
The test involves a small needle inserted into your arm, which may cause mild discomfort or bruising. Most people experience minimal pain or swelling afterward. Rarely, there may be a reaction to the needle or infection at the site, but these are uncommon side effects.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy