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Epstein-Barr Virus Nuclear Antigen IgM Antibody (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the nuclear antigen of Epstein-Barr virus (EBV), a common virus that can cause infections like mononucleosis. It helps determine if you’ve recently been exposed to EBV.

Quick summary

["Assesses recent EBV infection risk through IgM antibody presence in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109941-5
Short code
EBV NA IgM Msmt Ser
Synonyms
EBV NA IgM Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for IgM antibodies specific to EBV’s nuclear antigen. IgM antibodies are typically produced shortly after initial infection and can indicate a recent exposure to the virus. This test is not used to diagnose active EBV infection directly but can support evaluation in certain clinical scenarios.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms like fatigue, sore throat, or swollen lymph nodes that could suggest mononucleosis or other EBV-related conditions. It may also be used in research or specific diagnostic contexts where recent infection timing is relevant.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The serum portion is separated and sent to the lab for analysis. This test is typically performed on fresh or stored serum samples.

What to Expect Before the Test

No special preparation is needed. You may have some mild discomfort from the needle, but it usually resolves quickly. Avoid alcohol or certain medications for 24 hours before testing if instructed by your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

EBV IgM Antibody

Frequently asked questions

When might I get false-positive or false-negative results?
False positives are rare but can occur with cross-reacting antibodies or laboratory errors. False negatives are more likely if the test is done too early after infection (before IgM antibodies develop) or if the sample is improperly handled. Your provider may retest if initial results are unclear.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Follow-up with your healthcare provider to discuss results and next steps.
Can I have this test if I’m pregnant or breastfeeding?
Yes, this test is considered safe during pregnancy and breastfeeding. However, always discuss any medical tests with your healthcare provider to ensure it’s appropriate for your situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy