Skip to content

Epstein-Barr Virus Nuclear Antigen IgG Antibody (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures your body’s immune response to the Epstein-Barr virus (EBV), a common virus that can cause infections like mononucleosis. It helps track whether you’ve been exposed to EBV and if your immune system has developed antibodies over time.

Quick summary

["This test helps assess past exposure to EBV and long-term immune response."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6815-5
Short code
EBV NA IgM Ser Ql IA
Synonyms
EBV NA IgM Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms of EBV infection (such as fatigue, swollen lymph nodes, or sore throat), if you’ve been exposed to someone with EBV, or if you have a condition that affects your immune system. It can also be used to monitor chronic EBV infections or monitor immune response in certain conditions.

What to Expect Before the Test

No special preparation is needed for this test. You’ll provide a blood sample, usually drawn from your arm. The sample will be sent to a lab to detect specific antibodies in your serum or plasma.

What the Test Results Mean

A positive result indicates that your immune system has produced IgG antibodies against EBV, suggesting past infection. These antibodies remain in your blood for years, helping your body fight future infections. However, they don’t indicate whether you currently have an active EBV infection.

Common Reasons for Testing

This test is often used to diagnose or confirm a history of EBV infection, especially in cases where symptoms are unclear. It can also help evaluate conditions like chronic fatigue syndrome, certain lymphomas, or immune disorders where EBV is suspected.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

EBV IgG Antibody

Frequently asked questions

What does a positive result mean?
A positive result means your body has produced antibodies against EBV, indicating you’ve likely been infected at some point. This doesn’t mean you’re currently sick, but it confirms your immune system has recognized and responded to the virus.
Can this test detect an active EBV infection?
No, this test only detects IgG antibodies, which develop after an initial infection and persist long-term. To check for an active infection, your provider might order additional tests, such as EBV viral load or other antibody tests.
How long do EBV IgG antibodies last?
IgG antibodies typically remain in your blood for years after infection. Some people may have detectable levels for life, while others may see a gradual decline over time, especially if their immune system is compromised.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy