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Genetic analysis for EGFR mutation status (via probe-based assay) in plasma

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific genetic changes in a protein called EGFR that may be linked to certain types of lung cancer or other cancers. It uses a sample of your blood plasma to identify these mutations.

Quick summary

["Helps determine if targeted cancer treatments may be effective for your condition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63423-8
Short code
EC eaeA gene Spec Ql NAA+probe
Synonyms
EC eaeA gene Spec Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters in Cancer Care

EGFR mutations are genetic variations in the epidermal growth factor receptor gene. These mutations can make cancer cells grow and spread faster, sometimes responding differently to treatments like tyrosine kinase inhibitors. Identifying these mutations helps doctors choose the most appropriate treatment plan tailored to your cancer type and genetics.

How the Test Works

Your blood plasma is collected and analyzed using a specialized probe-based assay. This method detects specific DNA sequences associated with EGFR mutations. The test is designed to be highly sensitive and accurate for guiding treatment decisions.

Sample Collection and Preparation

A blood sample is drawn from your arm, and the plasma portion is separated and sent to the lab for testing. This process is similar to other blood tests and is typically done in a clinical setting by a healthcare professional.

What to Expect Before the Test

There are no special preparations needed for this test. You may eat and drink normally before the blood draw. If you are on blood-thinning medications, inform your healthcare provider beforehand.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: EGFR Mutations and Treatment Implications

Short name

EGFR Mutation Test (Plasma)

Frequently asked questions

What does a positive or negative result mean?
A positive result indicates the presence of EGFR mutations, which may mean your cancer could respond to targeted therapies like EGFR tyrosine kinase inhibitors. A negative result suggests these mutations are not present, and other treatment options may be considered. Results should always be interpreted by your healthcare team in the context of your overall diagnosis and medical history.
How often is this test repeated?
This test is usually performed once at the time of diagnosis or during treatment planning. However, some patients may undergo repeat testing if their cancer progresses or if they switch treatments. Your doctor will determine if retesting is necessary based on your treatment response and cancer progression.
Can this test be done on other types of specimens?
Primarily performed on plasma, though some advanced genetic testing may use other specimens like tumor tissue. Always confirm with your healthcare provider which specimen type is appropriate for your situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy