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Genetic probe for epidermal growth factor receptor (EGFR) mutations in circulating nucleic acids (cell-free DNA)

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific genetic changes in a small amount of DNA found naturally in your blood, which may help determine if targeted cancer treatments could be effective for you.

Quick summary

["A genetic test that may guide personalized cancer treatment options by identifying mutations linked to EGFR."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
88116-9
Short code
EC gene pnl Spec NAA+probe
Synonyms
EC gene pnl Spec NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test Used For?

This test analyzes circulating cell-free DNA (cfDNA) in your blood to detect mutations in the epidermal growth factor receptor (EGFR) gene. EGFR mutations are sometimes present in certain types of lung, colorectal, or other cancers and can influence treatment choices, such as targeted therapies.

How Is the Sample Collected?

A blood sample is drawn from your arm, similar to a regular blood test. The DNA from your blood cells is extracted and analyzed for EGFR mutations.

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have certain cancers (e.g., non-small cell lung cancer) and are being considered for targeted cancer treatments that specifically target EGFR mutations.

What Does a Positive Result Mean?

A positive result indicates the presence of EGFR mutations in your cfDNA. This finding may suggest that certain targeted therapies could be more effective for your cancer, but it does not confirm a diagnosis of cancer. Your doctor will discuss next steps with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

EGFR Mutation Test (cfDNA)

Frequently asked questions

What does a positive result mean for my cancer treatment?
A positive result means your cancer may have EGFR mutations that could respond to targeted therapies. Your doctor will discuss whether this test result supports a specific treatment plan, such as EGFR inhibitors, and how it fits with other diagnostic findings.
How long does it take to get results?
Results typically take 1–3 weeks, depending on lab processing times and your healthcare provider’s workflow. Your doctor will contact you once results are ready.
Is this test covered by insurance?
Coverage depends on your insurance plan, medical necessity, and whether your cancer type and treatment plan qualify. Check with your insurance provider or ask your doctor for details about costs and coverage before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy