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C-reactive protein (CRP) measured by chemiluminescent immunoassay (CLIA) in plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation in your body.

Quick summary

["CRP helps doctors assess inflammation, often used to monitor conditions like infections, autoimmune diseases, or after injury."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63427-9
Short code
EC stx1 Spec QI NAA+probe
Synonyms
EC stx1 Spec QI NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order CRP testing to check for signs of inflammation, monitor chronic conditions like arthritis or heart disease, or evaluate symptoms such as fever, pain, or swelling. It can also help guide treatment decisions or track how well a condition is responding to treatment.

What Does a High or Low CRP Level Mean?

A higher-than-normal CRP level often indicates inflammation, which can be caused by infections, injuries, or certain diseases. A very low level may suggest no active inflammation, but it’s not always definitive. Your doctor will interpret results in the context of your overall health and symptoms.

Sample Preparation and Testing Process

Blood is drawn from a vein in your arm, and the plasma is separated and sent to a lab for testing. The CRP level is measured using a sensitive immunoassay method to detect even small amounts of the protein.

Common Conditions Monitored with CRP

CRP is commonly used to monitor conditions like rheumatoid arthritis, inflammatory bowel disease, heart disease, or infections. It can also help assess the risk of future health problems, such as heart attacks or strokes, in some cases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

CRP plays a key role in identifying and managing inflammatory processes in the body. While it’s not specific to any single disease, elevated levels often signal widespread inflammation that may require further investigation or treatment adjustments. Doctors use CRP as part of a broader diagnostic and monitoring toolkit.

Short name

CRP (Plasma)

Frequently asked questions

What does a CRP test measure exactly?
The CRP test measures the concentration of C-reactive protein in your plasma. This protein is produced by your liver in response to inflammation or infection, helping your body identify and clear damaged cells or pathogens.
How often should I get a CRP test?
Your doctor will determine how often you need a CRP test based on your health condition, symptoms, and treatment plan. Some people may get it once a year or more frequently if they have chronic inflammation or a history of inflammatory diseases.
Can CRP levels change without a clear reason?
Yes, CRP levels can fluctuate due to factors like stress, recent illness, physical activity, or even diet. That’s why doctors consider CRP in the context of your overall health and other test results when making decisions about your care.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy