Genetic analysis for EGFR gene mutations (using a nucleic acid probe)
This test checks for specific changes (mutations) in the EGFR gene, which may be linked to certain types of cancer, including non-small cell lung cancer.
["Helps determine if targeted cancer treatments may be effective for your condition."]
Key facts at a glance
- LOINC
- 87377-8
- Short code
- EC stx2 gene Islt Ql NAA+probe
- Synonyms
- EC stx2 gene Islt Ql NAA+probe
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- probe-amp-tar
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may recommend this test if you have been diagnosed with a type of cancer that is suspected to be driven by EGFR gene mutations, such as non-small cell lung cancer. It helps guide treatment decisions by identifying whether certain targeted therapies could be beneficial.
How the Test Works
A small sample of your tumor tissue or blood is collected and analyzed using a specialized nucleic acid probe to detect specific mutations in the EGFR gene. This process identifies genetic variations that may respond to targeted medications.
Sample Collection and Preparation
The test requires either a tissue sample (such as a biopsy) or blood sample, depending on the type of cancer and clinical guidelines. Your healthcare provider will explain the process and ensure it is done safely and comfortably.
What to Expect Before the Test
No special preparation is usually needed for this test, but you may be asked to avoid certain medications or fasting, depending on the sample type. Follow your healthcare provider’s instructions closely.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results for EGFR mutations may indicate that certain targeted therapies (such as tyrosine kinase inhibitors) could be effective in treating your cancer. This information helps tailor treatment plans to improve outcomes and reduce side effects. Negative results suggest other treatments or approaches may be more appropriate.
Short name
EGFR Mutation Test
Frequently asked questions
What does a positive result mean?
What if my test result is negative?
How long will it take to get my results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy