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Total Protein in Serum (with Electrophoresis Profile)

Published: August 9, 2026Updated: August 16, 2026

This test measures the overall amount of protein in your blood serum, often used to assess overall protein status and identify potential imbalances.

Quick summary

["Blood protein levels help diagnose conditions like malnutrition, kidney disease, or liver problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31061-5
Short code
ECV11 Ab Titr Fld CF
Synonyms
ECV11 Ab Titr Fld CF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
comp-fix
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions affecting protein production, absorption, or loss in the body. It can also help evaluate kidney function, liver health, or nutritional status. Sometimes, an electrophoresis portion may be included to break down protein types (e.g., albumin vs. globulins).

What Does the Test Involve?

A blood sample is drawn from a vein, usually in your arm. The serum (liquid part after clotting) is analyzed for total protein content. If electrophoresis is included, the sample may be separated into different protein fractions for further evaluation.

What to Expect Before the Test

No special preparation is usually needed, but avoid heavy meals or excessive alcohol 24 hours before. If you’re on certain medications (e.g., steroids), let your provider know. Some tests may require fasting, but this is not applicable here.

What to Expect After the Test

You may feel slight discomfort at the injection site, but it should resolve quickly. Apply gentle pressure or an ice pack if needed. Monitor the area for signs of infection (e.g., redness, swelling). Report any unusual symptoms to your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

How long will I need to wait for results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will discuss findings during your follow-up visit.
What causes protein levels to change?
Changes in protein levels can result from diet, kidney or liver disease, infections, inflammation, or certain medications. Chronic conditions like diabetes or heart failure may also affect protein metabolism.
Do I need to prepare differently if electrophoresis is included?
If electrophoresis is part of the test, no additional preparation is needed beyond standard blood draw guidelines. Your provider will clarify if further steps are required.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy