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Serum or Plasma Creatinine Concentration (Standard Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["Kidney function depends on creatinine levels—high values may signal impaired kidney function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22272-9
Short code
ECV18 Ab Titr Ser
Synonyms
ECV18 Ab Titr Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Your Kidneys Matter

Creatinine is a byproduct of muscle breakdown that your kidneys filter from your blood. If your kidneys aren’t working well, creatinine builds up, which can affect other organs. This test helps doctors check for early kidney problems, especially in people with diabetes, high blood pressure, or a family history of kidney disease.

What to Expect Before the Test

No special preparation is needed unless your doctor instructs otherwise. You may have a small needle inserted into your arm or vein to draw blood. If you’re on a diet low in meat or protein, your doctor may ask you to avoid it for 24 hours before testing to get a more accurate result.

What the Results Mean

Results are compared to a standard range based on age, sex, and overall health. Higher-than-normal levels may indicate kidney problems, while very low levels could suggest muscle disorders or certain medical conditions. Your doctor will discuss the results with you in detail.

Common Causes of Abnormal Results

High creatinine levels can be caused by kidney disease, dehydration, severe muscle injury, or conditions like diabetes or heart failure. Low levels may be due to muscle wasting, liver disease, or certain medications. Always talk to your doctor about symptoms like swelling, fatigue, or changes in urine.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Creatinine Level

Frequently asked questions

How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and risk factors. For example, people with diabetes or kidney disease may need it more frequently than others.
What does it feel like to have blood drawn?
Most people feel a slight pinch or sting when the needle is inserted. Afterward, you may feel a small bruise or soreness at the site, but it usually goes away quickly. If you’re nervous, let your doctor know—they can use a numbing cream or take extra time to make it more comfortable.
Can I drink water before this test?
Yes, you can drink water before the test unless your doctor advises otherwise. Hydration helps ensure your kidneys are working normally, but avoid excessive fluids if you’re on a special diet or have been told to restrict fluids.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy