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Total Protein in Serum (or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein levels and kidney function.

Quick summary

["Blood protein levels can signal kidney health or nutritional needs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31062-3
Short code
ECV30 Ab Titr Fld CF
Synonyms
ECV30 Ab Titr Fld CF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
comp-fix
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions like kidney disease, liver problems, malnutrition, or dehydration. It can also help diagnose or monitor certain diseases, such as multiple myeloma or severe infections.

What Does a Low or High Protein Level Mean?

Low protein levels might indicate poor nutrition, kidney issues, or liver disease. High protein levels could suggest dehydration, kidney problems, or certain blood disorders.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum (if clotted) or plasma (if anticoagulated) for testing. This test does not require fasting.

Common Conditions Monitored

This test is often used to monitor kidney function, liver health, and nutritional status. It may also be part of routine check-ups or evaluations for conditions like chronic kidney disease or severe infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein Levels and Health

Short name

Total Protein

Frequently asked questions

How often will I need this test?
The frequency depends on your health condition and doctor’s recommendations. Some people may need it yearly, while others may need it more often if they have ongoing health issues.
What are the typical reference ranges for this test?
Reference ranges can vary by lab and individual health status. Your results will be compared to your specific lab’s standards and your doctor’s guidance.
Can I eat or drink anything before this test?
No special preparation is needed for this blood test, including fasting. However, always follow your doctor’s instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy