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Serum or plasma concentration of digoxin (digitalis glycoside)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of digoxin, a medication used to treat certain heart conditions, in your blood.

Quick summary

["Digoxin helps regulate your heart’s rhythm and strength; levels are checked to ensure safe dosing."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
61076-6
Short code
EDDP Gast Ql
Synonyms
EDDP Gast Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you’re taking digoxin for heart failure, atrial fibrillation, or other heart-related issues. It helps monitor whether your dose is working properly or if adjustments are needed to avoid side effects like irregular heartbeat or low potassium levels.

How the Test Works

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed using an immunoassay method to detect digoxin levels.

What to Expect Before the Test

No special preparation is needed, but inform your doctor about all medications, including over-the-counter drugs or supplements, as some can affect digoxin levels.

Possible Results and Interpretation

Results are compared to a general reference range, but exact values can vary by lab. Too-high levels may cause nausea, vision changes, or heart rhythm issues, while too-low levels might mean the medication isn’t working effectively.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Digoxin Level

Frequently asked questions

What causes digoxin levels to be checked regularly?
Regular digoxin level checks are typically done if you have heart conditions like heart failure or atrial fibrillation, or if you take digoxin long-term. Your doctor may also order it if you’re experiencing symptoms like nausea, vomiting, or irregular heartbeat, or if you’ve missed doses.
How often should digoxin levels be checked?
The frequency depends on your treatment plan. Some patients need levels checked weekly at first, then less often as their condition stabilizes. Your doctor will determine the best schedule for you.
Can lifestyle changes affect digoxin levels?
Yes, lifestyle factors like diet (e.g., high potassium foods), certain medications (like diuretics or antiarrhythmics), or illness (e.g., dehydration) can influence digoxin levels. Always discuss your routine with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy