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24-Hour Urinary Creatinine Clearance

Published: August 9, 2026Updated: August 16, 2026

This test measures how well your kidneys filter waste products, specifically creatinine, over a full day. It helps assess kidney function and blood flow to the kidneys.

Quick summary

["This test helps doctors check how well your kidneys are working and identify potential kidney problems early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111081-6
Short code
EDDP Msmt Ur
Synonyms
EDDP Msmt Ur
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Creatinine is a waste product from muscle metabolism that kidneys normally filter out of your blood. Clearance measures how efficiently your kidneys remove creatinine from your blood over 24 hours. This test is often used alongside blood creatinine levels to get a fuller picture of kidney function.

Why Is This Test Done?

Doctors may order this test if you have symptoms of kidney disease (like swelling, fatigue, or changes in urine), if you have a history of kidney problems, or if you’re taking medications that can affect kidney function. It’s also used before surgeries or procedures that may impact kidney function.

How Is This Test Performed?

You’ll collect all your urine over 24 hours in a special container. Your doctor will provide instructions on timing and storage. Blood may also be drawn at the start and end of the period to measure baseline creatinine levels for comparison.

What Are Common Results?

Results are typically reported as a clearance rate (e.g., in milliliters per minute or liters per day). Lower than expected values may indicate kidney damage or disease, while higher values could suggest overhydration or other conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Creatinine Clearance (24 hr urine)

Frequently asked questions

How Often Should I Get This Test?
The frequency depends on your health status. If you have kidney disease, your doctor may recommend regular monitoring. If you’re healthy, this test may only be done if you have risk factors (like diabetes, high blood pressure, or a family history of kidney issues).
What Do My Results Mean?
Your results will be compared to standard ranges for your age, sex, and overall health. If your clearance is significantly lower than expected, it may signal kidney problems that need further evaluation, such as blood tests or imaging.
Can I Eat or Drink Normally Before This Test?
Yes, you can eat and drink as usual, but follow your doctor’s specific instructions for timing. Avoid excessive alcohol or medications that might affect kidney function unless directed otherwise.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy