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Plasma or Serum Protein Electrophoresis (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, separated by size and charge, to help identify abnormalities in protein distribution.

Quick summary

["Protein electrophoresis helps detect conditions affecting protein levels, such as infections, cancers, or kidney disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
41860-8
Short code
EDDP SerPl Ql
Synonyms
EDDP SerPl Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to diagnose or monitor conditions like multiple myeloma, lymphoma, kidney disease, or chronic inflammatory diseases. It can also check for unusual protein patterns that might suggest genetic disorders or immune system issues.

How the Test Works

A small blood sample is taken, and the plasma or serum is separated from blood cells. The proteins are then applied to a gel and subjected to an electric current, causing them to move based on their size and electrical charge. Different protein bands appear, which are analyzed to identify any irregularities.

Sample Collection

A needle is used to draw blood from a vein, usually in your arm. The blood is processed to isolate plasma or serum, which is then sent to the lab for electrophoresis analysis.

Preparation

No special preparation is needed, but inform your provider if you are taking blood-thinning medications or have a history of bleeding disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Electrophoresis

Frequently asked questions

What does an abnormal electrophoresis result mean?
An abnormal result may show unusual bands or spikes, which could indicate conditions like multiple myeloma (extra protein bands), liver or kidney disease (altered protein distribution), or infections (changes in acute-phase proteins). Always discuss results with your healthcare provider.
How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on lab processing times. Your provider will explain the findings in detail during your follow-up visit.
Can I eat or drink before this test?
No special diet is required, but avoid alcohol for 24 hours before testing if instructed by your provider, as it may affect protein levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy