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Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Autoantibody, Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of antibodies directed against GM-CSF, an immune-system signaling protein. These antibodies can interfere with normal immune-cell function.

Quick summary

["Elevated anti-GM-CSF antibodies may be associated with immune dysfunction, recurrent infection, or inflammatory lung disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13229-0
Short code
EEEV IgM CSF-aCnc
Synonyms
EEEV IgM CSF-aCnc
Category
liver
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What is this test?

This test measures the concentration of autoantibodies directed against granulocyte-macrophage colony-stimulating factor, or GM-CSF. GM-CSF helps immune cells respond to infection and inflammation, and antibodies that neutralize it may affect immune-cell function.

Why might I need this test?

A clinician may order this test when unexplained immune deficiency, recurrent infections, certain inflammatory conditions, or unusual lung disease is being evaluated. It is often interpreted together with symptoms, immune-cell counts, immunoglobulin levels, and other laboratory findings.

How is the test performed?

A laboratory measures anti-GM-CSF antibodies in a patient sample, usually blood, using an antibody-based assay. The laboratory should confirm the required specimen and testing method before collection.

How do I prepare for the test?

No special preparation is usually required for a routine blood-based antibody test. Follow the instructions provided with your laboratory order, particularly if a different specimen is required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

GM-CSF autoantibody

Frequently asked questions

What does a positive result mean?
It means detectable antibodies against GM-CSF were found. Depending on the laboratory's reporting method, this may represent a normal finding or an abnormal amount that requires clinical interpretation.
Can these antibodies affect the immune system?
Yes. Anti-GM-CSF antibodies can neutralize GM-CSF and potentially reduce the ability of certain immune cells to respond to infection.
Does this test diagnose one specific condition?
No. The result may support evaluation for immune deficiency, recurrent infection, autoimmune disease, or lung disease, but it must be interpreted with symptoms and other test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy