EGFR Gene Mutation Analysis, Blood
A blood test that checks for selected changes in the EGFR gene. Results may help guide cancer treatment when EGFR-targeted therapy is being considered.
["This test looks for EGFR gene changes that may affect selection or monitoring of targeted cancer medicines."]
Key facts at a glance
- LOINC
- 21665-5
- Short code
- EGFR gene Mut Anl Bld/T
- Synonyms
- EGFR gene Mut Anl Bld/T
- Category
- kidney
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 90
- Ref high
- 120
- Critical range
- 15 N/A – —
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- CPT
- 82565
- SNOMED
- 247997009
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
EGFR is a gene that helps cells grow and divide. This test examines blood for selected changes, also called mutations, in the EGFR gene.
Why might I need this test?
This test may be ordered during evaluation or treatment of cancer. EGFR mutations can sometimes help determine whether medicines that target EGFR may be appropriate and may also be used to monitor certain forms of drug resistance.
How is the test performed?
A blood sample is collected, and the laboratory analyzes genetic material to look for selected EGFR mutations. The exact testing method depends on the laboratory, and a blood test may not detect a mutation that is present only in a tumor.
How do I prepare for the test?
No special preparation is usually required. Follow the laboratory's collection instructions, and tell the healthcare team if you recently received chemotherapy, blood transfusion, or another procedure that could affect the sample.
Reference range
Normal: >90 mL/min/1.73m²N/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Detection of an EGFR mutation may provide information about prognosis and possible targeted treatment options. A negative result does not always rule out an EGFR mutation because some variants may not be present in blood or may not be included in the test's scope. Results should be interpreted by a healthcare professional along with the diagnosis and other test findings.
Short name
EGFR gene mutation blood test
Frequently asked questions
Does a positive result mean I have cancer?
Can this blood test replace tumor testing?
Will I need to stop any medicines before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy