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Total Protein in Serum or Plasma (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes important substances like albumin and globulins that help maintain fluid balance and support immune function.

Quick summary

["Total protein helps assess overall health and identify potential issues like dehydration, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6725-6
Short code
Egg White IgG Qn
Synonyms
Egg White IgG Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your doctor may order this test to check for conditions affecting protein levels, such as malnutrition, chronic kidney disease, or liver disorders. It can also help monitor treatments for conditions like nephrotic syndrome or certain infections.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if your doctor recommends it, but this is rare for a simple protein measurement. Bring any medications or questions to your appointment.

How the Test Works

A small blood sample is drawn from a vein in your arm. The sample is sent to a lab where it is analyzed to determine the total protein concentration. Results are typically available within 1–3 business days.

Possible Results & Next Steps

If your results are outside the expected range, your doctor may order additional tests to investigate underlying causes, such as checking albumin levels separately or evaluating kidney/liver function.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low protein levels?
Low protein levels can result from poor nutrition, kidney disease, liver problems, or conditions that cause excessive protein loss (e.g., heavy sweating, diarrhea). Chronic illness or certain medications may also affect protein production.
Results are usually ready within 1–3 business days, depending on your lab’s processing time. Your doctor will contact you once they have the final report.
Dietary protein intake generally doesn’t directly impact this test unless your doctor specifically instructs you to fast. However, if you have kidney or liver issues, they may recommend dietary adjustments to support your health.
High protein levels may indicate dehydration, severe infections, or certain blood disorders. Your doctor will review your medical history and may recommend further tests to determine the cause.
The blood draw itself is mild discomfort, but most people tolerate it well. A small bandage or bandage may be applied afterward. If you’re nervous, let your healthcare provider know—they can offer tips to make it more comfortable.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy