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Total Protein in Serum (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum. Proteins are essential for many bodily functions, including transporting nutrients, maintaining fluid balance, and supporting immune responses.

Quick summary

["Your blood protein levels help assess overall health and detect potential issues like malnutrition or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48226-5
Short code
Egg White LR-mCnc
Synonyms
Egg White LR-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It Matters in Your Health

Blood proteins play a critical role in your body’s health. They help carry important substances like vitamins and hormones, support immune function, and maintain proper fluid balance in your tissues. Abnormal protein levels can signal conditions such as kidney disease, liver problems, or malnutrition.

What to Expect During the Test

A simple blood draw is used to collect serum for this test. No special preparation is usually needed, but fasting may be advised depending on your healthcare provider’s instructions. The test is quick and typically done in a clinic or lab setting.

Common Conditions Monitored

Healthcare providers may order this test to check for conditions like chronic kidney disease, liver disease, dehydration, or malnutrition. It can also help diagnose or monitor certain autoimmune disorders or infections.

Factors That Can Affect Results

Several factors may influence your protein levels, including diet (especially protein intake), hydration status, certain medications, or underlying health conditions. Recent illness, stress, or physical activity can also temporarily affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What does a low or high protein level mean?
Low protein levels may indicate problems with your kidneys, liver, or digestive system, which can prevent your body from absorbing enough protein from food. Very low levels can lead to weakness, swelling, or an increased risk of infections. High protein levels might suggest dehydration, inflammation, or certain medical conditions that cause the body to produce extra protein.
How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and other tests. Some people may need it yearly, while others may need it more or less frequently depending on their condition.
Can I eat or drink before this test?
Follow your doctor’s instructions regarding food and drink before the test. Typically, fasting may not be required unless specified, but it’s best to avoid heavy meals or excessive fluids to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy