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Serum or plasma cholesterol (total)

Published: August 9, 2026Updated: August 17, 2026

This test measures the total amount of cholesterol in your blood, which includes both the cholesterol your body makes and that which comes from foods.

Quick summary

["Cholesterol levels help assess your risk for heart disease and other health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
102288-8
Short code
Egg Yolk IgE RAST
Synonyms
Egg Yolk IgE RAST
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rast
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for high cholesterol, which can increase your risk of heart disease, stroke, or other health problems. It’s often part of routine check-ups or if you have risk factors like high blood pressure, diabetes, or a family history of heart disease.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a lipid panel. If you’re unsure, ask your doctor. Blood is drawn from a vein, usually in your arm, and it usually takes a few minutes.

What the Results Mean

Results are typically reported as a single number (total cholesterol) rather than separate values for HDL, LDL, or triglycerides. High levels may signal the need for lifestyle changes or medication to manage cholesterol.

Common Causes of Abnormal Results

High cholesterol can result from diet, genetics, or underlying health conditions like obesity or diabetes. Low levels may occur if your body isn’t absorbing enough fat or if you have certain medications.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Cholesterol plays a critical role in cell function, but high levels of certain types (like LDL) can build up in arteries, increasing the risk of heart disease. Regular monitoring helps manage this risk.

Short name

Total cholesterol

Frequently asked questions

What does a high total cholesterol level mean?
A high total cholesterol level may indicate an increased risk of heart disease or other health issues. Your doctor will discuss your results and recommend next steps, such as diet changes or medications.
How can I lower my cholesterol naturally?
Eating a balanced diet rich in fruits, vegetables, and whole grains, reducing saturated and trans fats, and staying physically active can help lower cholesterol levels over time.
Do I need to fast before this test?
If this is part of a lipid panel, fasting for 8–12 hours before the test is usually required. Always follow your doctor’s instructions to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy