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Cerebrospinal Fluid White Blood Cell Count (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks the number of white blood cells in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord. It helps identify infections, inflammation, or other conditions affecting the central nervous system.

Quick summary

["A CSF white blood cell count helps diagnose potential infections or immune responses in your brain or spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47406-4
Short code
E histolyt Ab CSF Ql
Synonyms
E histolyt Ab CSF Ql
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Matters

White blood cells in the CSF are normally very low or absent. Elevated counts can signal conditions like meningitis, encephalitis, or other inflammatory processes. The test is often performed alongside other CSF tests (such as protein or glucose levels) for a full assessment.

How the Test Works

A small sample of CSF is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then examined under a microscope to count white blood cells. This is a qualitative test, meaning it provides a yes/no or low/high indication rather than a precise number.

When You Might Need This Test

Your doctor may order this test if you have symptoms like severe headache, neck stiffness, fever, confusion, or neurological symptoms (e.g., numbness, weakness). It’s also used to monitor conditions like multiple sclerosis or other central nervous system diseases.

What to Expect Before the Test

You’ll likely receive a local anesthetic to numb the area where the needle will be inserted. You may need to lie still for a short time afterward. Avoid heavy lifting or strenuous activity for 24 hours to prevent complications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF WBC Qual

Frequently asked questions

What does an elevated white blood cell count in CSF mean?
An increased count suggests an infection (e.g., bacterial or viral meningitis), inflammation, or other immune responses in the central nervous system. A normal result doesn’t rule out all causes, so your doctor may order additional tests.
What if my test results are abnormal?
Abnormal results will guide further testing, such as cultures, imaging, or additional CSF analyses. Your doctor will discuss next steps based on your symptoms and overall health.
Does this test require fasting?
No fasting is needed for this test. However, inform your doctor about any medications or conditions that might affect results, such as recent infections or immune-suppressing treatments.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy