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Histamine concentration in plasma (24-hour urine collection)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of histamine, a chemical released by certain cells in your body, over a 24-hour period in your urine. Histamine plays a role in allergic reactions and inflammation.

Quick summary

["Helps assess histamine-related conditions like allergic reactions or mast cell disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
105905-4
Short code
E histolyt DNA Stl Ql
Synonyms
E histolyt DNA Stl Ql
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84484
SNOMED
302774002
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms suggestive of histamine intolerance, such as flushing, headaches, or digestive issues after consuming certain foods. It could also be used to evaluate conditions like mastocytosis or other histamine-related disorders.

What to Expect Before the Test

You’ll need to collect all urine for a full 24-hour period, typically starting after you urinate in the morning of the first day. Store the urine in a refrigerator and return it to the lab on time. Follow any specific instructions your healthcare provider gives you to ensure accurate results.

What Happens During the Test

No special preparation is required beyond the urine collection. The lab will analyze the collected urine sample to measure histamine levels.

What the Results Mean

Results are compared to reference ranges for histamine in urine, though exact values may vary by lab. Elevated levels may suggest excessive histamine release, while normal levels help rule out histamine-related conditions.

Reference range

Adult: 10-40 U/LN/A

Specimen: stool

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Histamine

Frequently asked questions

What does a high histamine level in urine mean?
High levels may indicate conditions such as histamine intolerance, mastocytosis, or other disorders involving abnormal histamine production or release. Your doctor will consider your symptoms and other test results to make a diagnosis.
What does a low histamine level in urine mean?
Low levels may suggest normal histamine metabolism or could be due to certain medications or conditions that reduce histamine release. It’s important to discuss these results with your doctor to understand their relevance to your health.
How often should I get this test?
This test is typically ordered as needed based on your symptoms or clinical concerns. Your doctor will determine the frequency of testing based on your ongoing health situation and treatment plan.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy