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Serum or Plasma Alpha-1 Antitrypsin (A1AT) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced mainly in the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung disease and liver problems; low levels may indicate genetic risk or underlying conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63388-3
Short code
ENA Ab Fld IA-aCnc
Synonyms
ENA Ab Fld IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Alpha-1 Antitrypsin is crucial for lung and liver health. Low levels can increase your risk of chronic lung diseases like emphysema or liver disorders, especially if you have a family history of genetic mutations affecting this protein.

What to Expect Before the Test

No special preparation is needed. You may have blood drawn from a vein in your arm. If you’re taking blood thinner medications, let your provider know before the test.

How the Test Works

Blood is drawn and sent to a lab where it’s analyzed to measure the concentration of Alpha-1 Antitrypsin. The result helps assess your risk for lung or liver disease.

Possible Results and Next Steps

Results may be below, within, or above normal ranges. If low, further genetic testing or monitoring may be recommended, especially if you have symptoms like chronic cough or shortness of breath.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Alpha-1 Antitrypsin Deficiency

Short name

Alpha-1 Antitrypsin Level

Frequently asked questions

What causes low Alpha-1 Antitrypsin levels?
Low levels are often genetic and inherited, but they can also result from liver disease, chronic inflammation, or certain medications. If you have a family history of lung or liver disease, this test may be particularly important.
How might my results affect my health?
If your results indicate low levels, your healthcare provider may recommend lung function tests, lung imaging, or monitoring for liver issues. Early intervention can help manage symptoms and slow disease progression.
Can lifestyle changes help if I have low Alpha-1 Antitrypsin?
Yes! Quitting smoking, maintaining a healthy weight, and avoiding lung irritants like air pollution can help protect lung health. Some people with deficiency may also benefit from enzyme replacement therapy, which requires medical supervision.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy