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Serum Creatinine Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle breakdown, in your blood serum. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function and detect early kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
11565-9
Short code
ENA Jo1 Ab Ser-aCnc
Synonyms
ENA Jo1 Ab Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a byproduct of muscle metabolism that the kidneys filter out of your blood. High levels can indicate poor kidney function, while low levels may suggest overhydration or other conditions. This test is often used alongside other measures to evaluate kidney health, especially in people with risk factors like diabetes, high blood pressure, or a family history of kidney disease.

How the Test Works

A small blood sample is drawn from your arm. The lab then uses a specialized method (likely enzymatic or nephelometric) to measure the concentration of creatinine in your serum. Results are reported in units of mass concentration (e.g., mg/dL or µmol/L), though exact ranges vary by lab.

Common Reasons for Testing

Your doctor may order this test if you have symptoms like swelling, frequent urination, fatigue, or if you’re at risk for kidney problems. It’s also part of routine check-ups for people with chronic conditions like diabetes or high blood pressure.

Possible Results and Next Steps

Results may be compared to your baseline or reference ranges provided by your lab. If levels are unusually high, your doctor may recommend further testing or adjustments to your treatment plan, such as monitoring blood pressure or fluid intake.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Creatinine Level

Frequently asked questions

What does a high creatinine level mean?
A high creatinine level may signal reduced kidney function, meaning your kidneys aren’t filtering blood as well as they should. This can happen due to kidney disease, dehydration, or conditions like heart failure. Your doctor will consider the overall clinical picture, including other test results and symptoms, to determine if further evaluation is needed.
What does a low creatinine level mean?
Low creatinine levels can occur if you’re overhydrated, have very little muscle mass, or are taking certain medications that affect kidney function. In some cases, it may also indicate an error in testing or a medical condition like liver disease. Your doctor will discuss the results with you in the context of your health history.
Can diet affect creatinine levels?
Yes, diet can influence creatinine levels. Eating high-protein foods may temporarily increase creatinine because muscle breakdown produces more waste. However, the test itself measures the *current* level in your blood, not diet history. If you’re concerned about diet, discuss it with your doctor before testing, especially if you have kidney-related questions.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy