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Serum or Plasma Creatinine Concentration (Standard Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of creatinine, a waste product from muscle breakdown, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test is a key part of kidney function evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
56731-3
Short code
ENA Jo1 Ab Ser Ql IB
Synonyms
ENA Jo1 Ab Ser Ql IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine levels can indicate how efficiently your kidneys are working. High levels may suggest kidney damage or disease, while low levels could be due to muscle mass changes or other conditions. This test is often used alongside other measures to monitor kidney health, especially in people with risk factors like diabetes or hypertension.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood draw (serum or plasma) or, less commonly, a urine sample (though the slug suggests serum/plasma). If you’re on a low-protein diet, discuss it with your provider, as it may affect results.

Common Causes of Abnormal Results

Elevated creatinine levels may be caused by reduced kidney function, dehydration, severe muscle injury, or certain medications. Low levels might result from muscle atrophy, overhydration, or conditions like liver disease. Always discuss symptoms or medications with your healthcare team.

How Results Are Interpreted

Results are typically compared to your baseline or clinical context rather than absolute reference ranges. Your provider will use them alongside other tests (like blood urea nitrogen or glomerular filtration rate) to assess kidney function.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Creatinine

Frequently asked questions

What might cause my creatinine level to be high?
High creatinine levels can signal kidney problems, including chronic kidney disease (CKD), acute kidney injury, or conditions that reduce blood flow to the kidneys (e.g., severe dehydration or heart failure). Other causes may include muscle disorders, certain medications, or metabolic disorders. Always consult your healthcare provider for personalized interpretation.
Why do I need this test if I don’t have symptoms?
Even without symptoms, your provider may order creatinine tests to monitor kidney health, especially if you have risk factors like diabetes, high blood pressure, a family history of kidney disease, or are taking medications that affect kidney function. Regular monitoring helps detect issues early.
Can diet affect my creatinine test results?
Yes, diet can influence creatinine levels. High-protein diets may temporarily increase creatinine, while low-protein diets can lower it. If you’re on a special diet, inform your provider before testing to avoid misleading results. Hydration status also plays a role—dehydration can raise creatinine levels.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy