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Serum or Plasma Immunoassay for Anti-Neutrophil Cytoplasmic Antibodies (ANCA) Profile

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies in your blood that target proteins in neutrophils, a type of white blood cell. These antibodies can indicate certain autoimmune conditions, including vasculitis.

Quick summary

["This test helps diagnose or monitor autoimmune diseases affecting blood vessels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109295-6
Short code
ENA Jo1 IgG Msmt Ser
Synonyms
ENA Jo1 IgG Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects three main types of ANCA antibodies: proteinase 3 (PR3), myeloperoxidase (MPO), and others that may target different neutrophil proteins. These antibodies are linked to specific types of vasculitis, an inflammation of blood vessels.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like rash, joint pain, kidney problems, or unexplained infections. It’s also used to confirm a diagnosis of conditions like Wegener’s granulomatosis or microscopic polyangiitis.

What to Expect Before the Test

No special preparation is needed, but you may fast for 8–12 hours before drawing blood if instructed. Bring your test results or doctor’s notes if you’ve had this test before.

What Happens During the Test?

A healthcare provider will draw blood from a vein in your arm. The sample is sent to a lab for testing using an immunoassay method to detect ANCA antibodies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: ANCA Antibodies and Autoimmune Conditions

Short name

ANCA Antibody Test

Frequently asked questions

Why is this test important?
This test is critical for diagnosing vasculitis, a group of rare but serious conditions where blood vessels become inflamed. Early detection improves treatment outcomes and helps prevent complications like organ damage or stroke.
Can ANCA antibodies be present without a disease?
Yes, some people may have ANCA antibodies without symptoms or disease. However, if antibodies are detected alongside symptoms, further testing and evaluation are needed to determine the cause.
How often should this test be repeated?
Your doctor will determine how often to repeat the test based on your symptoms, treatment plan, and lab results. Follow-up may include monitoring for changes in antibody levels or symptoms over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy