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Serum/plasma concentration of angiotensin-converting enzyme (ACE)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of angiotensin-converting enzyme (ACE) in your blood. ACE is an enzyme involved in regulating blood pressure and fluid balance.

Quick summary

["ACE levels can help diagnose or monitor conditions affecting the lungs, kidneys, or immune system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73400-4
Short code
Enalapril ind plt IgM SerPl Ql FC
Synonyms
Enalapril ind plt IgM SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What ACE Levels Tell Us About Your Health

ACE is primarily produced by cells in the lungs, kidneys, and blood vessels. Elevated ACE levels may suggest conditions like sarcoidosis, certain infections, or exposure to environmental toxins. Lower than expected levels might indicate genetic variations or rare enzyme deficiencies.

Common Conditions Linked to ACE Levels

High ACE levels are sometimes seen in conditions like lymphangioleiomyomatosis (LAM), certain infections (e.g., *Mycobacterium*), or exposure to organophosphate pesticides. Very low levels are uncommon but could relate to genetic factors or specific enzyme disorders.

How This Test Is Performed

A blood sample is drawn from a vein, typically in your arm. The sample is processed to separate serum or plasma, where ACE levels are measured using an immunoassay method. Results are reported as a concentration value.

What to Expect Before or After the Test

No special preparation is needed, but inform your provider if you’re on blood thinners or have a history of bleeding disorders. After the draw, you may experience mild bruising or soreness at the site, which usually fades quickly.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance of ACE Levels

Short name

ACE Level

Frequently asked questions

Why might my ACE level be checked?
Your healthcare provider may order this test if you have symptoms like persistent cough, shortness of breath, or unexplained weight loss. It’s also used to monitor conditions like sarcoidosis, certain cancers, or immune-related diseases.
What do my ACE results mean?
Results alone don’t diagnose a condition—they’re part of a broader evaluation. High levels may raise concerns for specific lung or kidney diseases, while low levels are less common and usually require further investigation.
How often should I get this test?
Frequency depends on your health status. If you have a known condition linked to ACE, your provider may recommend regular monitoring. Otherwise, this test is rarely routine unless symptoms appear.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy