Line Blot Immunoassay for Antibodies to Neisseria meningitidis (Group B) (MenB)
This test detects antibodies your immune system produces in response to *Neisseria meningitidis* Group B bacteria, which can cause serious infections like meningitis.
["Helps assess immunity after vaccination or exposure to meningococcal bacteria."]
Key facts at a glance
- LOINC
- 89537-5
- Short code
- ENA PCNA Ab CSF Ql Line blot
- Synonyms
- ENA PCNA Ab CSF Ql Line blot
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
This test measures specific substances, markers, or cells in your body that can show how well certain organs are working, whether an infection or disease may be present, and how a current treatment is affecting your overall health over time.
A line blot immunoassay (LIA) detects specific antibodies against Group B meningococcal antigens. The test uses a qualitative method to identify whether your blood contains these antibodies, which may indicate prior exposure or vaccination effectiveness.
Your healthcare provider may order this test to help diagnose a new medical problem, monitor a condition you already have, check how well your treatment is working, or screen for potential health issues before noticeable symptoms appear.
Doctors may order this test if you’ve received the meningococcal B vaccine, had recent exposure to someone with meningococcal disease, or if you’re at higher risk (e.g., college students, travelers to regions with higher infection rates). It helps confirm whether your body has mounted an immune response.
A trained professional will collect a small sample, such as blood, urine, or a swab, depending on the type of test. You may receive simple instructions beforehand, such as fasting for a set number of hours, avoiding certain foods or medicines, or drinking extra water.
A blood sample is drawn from a vein in your arm. The serum (liquid part of blood) is separated and tested for antibodies using a specific line blot assay that reacts with Group B meningococcal antigens.
Before your test, plan to arrive a few minutes early and bring your photo identification, insurance card, and any paperwork or orders from your provider. Tell the staff about all medicines, supplements, and allergies you have, and ask questions if any instruction seems unclear.
No special preparation is needed, but inform your provider if you’re on blood-thinning medications or have a history of bleeding disorders. Wear comfortable clothing for the blood draw.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
MenB Antibody Screening/Confirmation
Frequently asked questions
Positive results suggest your immune system has recognized and responded to Group B meningococcal bacteria, often after vaccination. However, a positive result does not guarantee full protection—consult your provider for guidance on vaccination status or booster recommendations. Negative results may indicate insufficient immunity and warrant further evaluation or booster administration.
A positive result means your blood contains antibodies against Group B meningococcal bacteria, which may indicate prior exposure or vaccination. This does not replace medical advice—your provider will discuss next steps based on your health history and risk factors.
Results are typically available within 1–3 business days. Your provider will contact you to discuss the findings and next steps.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy