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Serum or plasma concentration of angiotensin-converting enzyme (ACE)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of angiotensin-converting enzyme (ACE), an enzyme involved in regulating blood pressure and fluid balance in your body. It may be used to help diagnose or monitor certain conditions.

Quick summary

["ACE levels can help identify conditions affecting lung or lymphatic systems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5276-1
Short code
ENA PCNA Ab Ser Ql ID
Synonyms
ENA PCNA Ab Ser Ql ID
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-diffusion
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may order an ACE test to investigate symptoms such as shortness of breath, persistent cough, or swelling in the legs or abdomen. It can also be used to monitor conditions like sarcoidosis, certain types of lymphoma, or chronic obstructive pulmonary disease (COPD).

What Does the Test Involve?

A blood sample is taken from a vein, usually in your arm. The sample is then sent to a lab where the enzyme activity is measured. The test can be performed on either serum (blood plasma without blood cells) or plasma (blood plasma with blood cells).

What to Expect Before the Test

No special preparation is usually needed for this test. However, if you are on certain medications or have a condition that might affect your blood pressure or fluid balance, inform your healthcare provider beforehand.

What Are Possible Results?

Results can vary widely depending on the individual and the specific condition being evaluated. Your healthcare provider will interpret the results in relation to your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated ACE levels may be associated with conditions like sarcoidosis, certain lymphomas, or chronic infections. Lower than normal levels might suggest conditions affecting the kidneys or other factors influencing enzyme production. Always discuss any changes in your results with your healthcare provider.

Short name

ACE Level

Frequently asked questions

What does an ACE test measure?
An ACE test measures the concentration of angiotensin-converting enzyme (ACE) in your blood. ACE plays a role in blood pressure regulation and fluid balance.
How is the ACE test performed?
The test involves drawing a small amount of blood from a vein. The blood sample is then analyzed in a lab to measure ACE levels.
Can I eat or drink before the ACE test?
You can typically eat and drink normally before the ACE test unless your healthcare provider gives specific instructions. No special preparation is required.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy