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C-Reactive Protein (CRP) by Immunoassay (Plasma/Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when inflammation is present, often used to check for infection, injury, or autoimmune conditions.

Quick summary

["Helps track inflammation levels in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
82841-8
Short code
ENA PCNA IgG Titr Ser IF
Synonyms
ENA PCNA IgG Titr Ser IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82977
SNOMED
3110003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to monitor signs of inflammation, assess risk for heart disease, or evaluate conditions like infections, arthritis, or other autoimmune diseases. High-sensitivity CRP is particularly useful for detecting low-level inflammation that might not be obvious otherwise.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw from a vein in your arm. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Results are not given as a single number but as a trend or comparison to your baseline. Elevated levels may signal inflammation, while normal levels suggest low or stable inflammation. Your doctor will interpret results in the context of your health history and other tests.

Common Conditions Monitored

This test is often used to track conditions like rheumatoid arthritis, lupus, heart disease, or infections. It can also help guide treatment decisions for chronic inflammatory diseases.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated CRP levels may indicate an active inflammatory process, such as an infection, injury, or autoimmune response. Low or normal levels generally suggest minimal inflammation, but results should always be reviewed by a healthcare provider.

Short name

CRP (High-Sensitivity)

Frequently asked questions

What causes CRP levels to be higher than usual?
CRP can rise due to infections (like pneumonia or urinary tract infections), injuries, surgeries, or certain medical conditions such as rheumatoid arthritis or heart disease. Stress, smoking, or obesity may also influence CRP levels.
How often should I get this test?
Your doctor will determine how often you need this test based on your health needs. Some people get it yearly to monitor heart disease risk, while others may need it more frequently if they have an ongoing condition like arthritis.
Can diet or lifestyle changes affect CRP levels?
Yes, lifestyle factors like diet, exercise, smoking, and weight can impact CRP levels. Eating a heart-healthy diet, staying active, and avoiding smoking may help lower inflammation over time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy