Electrochemiluminescence Immunoassay for Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in Serum

Why This Test Is Done

Your doctor may order this test if you have symptoms such as persistent rash, unexplained joint pain, kidney problems, or unexplained lung issues. It helps identify whether your body’s immune system is attacking your blood vessels, which can cause inflammation and damage.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood, similar to other routine blood tests. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Positive results suggest the presence of ANCA antibodies, which can signal conditions like granulomatosis with polyangiitis (Wegener’s), microscopic polyangiitis, or Churg-Strauss syndrome. However, a positive test alone doesn’t confirm a diagnosis—additional tests and clinical evaluation are needed.

Common Conditions Linked to ANCA

This test is primarily used to support a diagnosis of vasculitis, a group of rare diseases where blood vessels become inflamed. It’s not a standalone test for other conditions like lupus or rheumatoid arthritis.