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Total Protein in Serum (Electrophoresis)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes proteins like albumin and globulins. Proteins help maintain fluid balance, support immune function, and transport nutrients.

Quick summary

["Blood protein levels can reflect overall health, hydration status, and certain medical conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63398-2
Short code
ENA RNP Ab Fld IA-aCnc
Synonyms
ENA RNP Ab Fld IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like malnutrition, kidney disease, liver problems, or infections. It can also help diagnose or monitor diseases such as multiple myeloma, nephrotic syndrome, or chronic inflammatory conditions.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it involves a blood draw, but this is not always required for protein electrophoresis alone. Bring any medications or questions to your appointment.

How the Test Is Performed

A healthcare professional will draw blood from a vein in your arm using a small needle. The blood sample is then sent to a lab for analysis, where proteins are separated and measured using electrophoresis.

What the Results Mean

Results are typically reported as a total protein concentration in grams per deciliter (g/dL). Abnormal results may indicate imbalances in protein types, which can signal underlying health issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Changes in total protein levels can signal conditions like dehydration, severe infections, liver or kidney disease, or certain cancers. Low protein levels may indicate malnutrition or excessive protein loss, while high levels could suggest conditions like multiple myeloma or chronic inflammation.

Short name

Total Serum Protein

Frequently asked questions

What causes abnormal protein levels in blood tests?
Abnormal protein levels can result from conditions like kidney disease, liver problems, infections, or certain cancers. Dietary factors (e.g., excessive protein intake) or medications may also influence results.
How long does it take to get my protein test results?
Results are usually available within 1–3 business days, depending on your lab’s processing time. Your healthcare provider will discuss the findings with you during your follow-up visit.
Can I eat or drink before this test?
No strict fasting is required for this test, but follow your provider’s instructions if combined with other blood tests. Hydration is important, but avoid excessive fluids that could dilute results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy