Skip to content

Serum or Plasma Creatinine Concentration (Substance Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or body fluid. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function and detect early kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109922-5
Short code
ENA Scl70 Ab Msmt Fld
Synonyms
ENA Scl70 Ab Msmt Fld
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to monitor kidney health, especially if you have symptoms like swelling, fatigue, or changes in urine output. It’s also used before certain procedures, during pregnancy, or if you have conditions like diabetes or high blood pressure.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader kidney function panel. Drink plenty of water the day before to help dilute creatinine levels if needed.

How the Test Is Performed

A blood sample is drawn from a vein in your arm, or a fluid sample (like urine or body fluid) may be collected. The sample is sent to a lab for testing.

What the Results Mean

Higher-than-normal levels may indicate kidney problems, while lower levels could suggest muscle breakdown or dehydration. Your doctor will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels are a key marker for kidney function. Elevated levels often signal impaired kidney filtration, which can lead to chronic kidney disease (CKD), acute kidney injury, or other conditions like fluid overload or electrolyte imbalances. Regular monitoring helps manage these risks and adjust treatments like medications or diet.

Short name

Creatinine Level

Frequently asked questions

What causes creatinine levels to be higher than usual?
Higher creatinine levels can result from reduced kidney function, dehydration, severe muscle damage, or conditions like heart failure or liver disease. Chronic kidney disease, diabetes, or high blood pressure may also contribute.
What causes creatinine levels to be lower than usual?
Lower-than-normal creatinine levels may occur with muscle atrophy, malnutrition, or overhydration. Rarely, it could indicate errors in lab testing or conditions like severe liver disease.
Do I need to do anything special after the test?
No special follow-up is needed unless your doctor requests additional tests or monitoring. If you had a blood draw, apply gentle pressure to the site to stop bleeding, and check for redness or swelling. If you experience dizziness or pain, contact your doctor.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy