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Serum Anti-Smooth Muscle Antibody (ASMA) Titration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies against smooth muscle proteins in your blood, which can help identify autoimmune conditions affecting organs like the liver or gastrointestinal tract.

Quick summary

["ASMA antibodies may signal autoimmune liver diseases or other inflammatory conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17589-3
Short code
ENA SM Ab Titr Ser ID
Synonyms
ENA SM Ab Titr Ser ID
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-diffusion
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is ASMA Used For?

ASMA antibodies are often checked in people with unexplained liver problems, persistent nausea, or symptoms like fatigue, jaundice, or abdominal pain. It may also be used in diagnosing conditions like autoimmune hepatitis or other connective tissue disorders.

How Is the Test Done?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it’s analyzed using an immunoassay method to detect and measure the ASMA antibody levels.

What Might High or Low Results Indicate?

Elevated ASMA levels may suggest autoimmune liver disease or other inflammatory conditions, but results alone don’t confirm a diagnosis. Your doctor will consider symptoms, other test results, and medical history.

How Often Is This Test Ordered?

ASMA testing is typically done as part of a broader evaluation for autoimmune disorders. It may be repeated if symptoms persist or if further monitoring is needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

ASMA Antibody Test

Frequently asked questions

Why was I asked to have this test?
Your doctor may recommend this test if you have symptoms like persistent liver issues, unexplained fatigue, or signs of an autoimmune condition. It helps narrow down possible causes.
What do my results mean?
Results may be normal or elevated. Normal results suggest no significant ASMA antibodies are present, but abnormal results don’t always mean a specific diagnosis. Your doctor will discuss findings with you.
Can I prepare for this test?
No special preparation is needed. You may have a light meal before the test, but avoid heavy or fatty foods. Follow any fasting instructions your doctor provides if applicable.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy