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Anti-Saccharomyces cerevisiae antibodies (ASCA) – Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies against *Saccharomyces cerevisiae* (a type of yeast), often used to help diagnose conditions like inflammatory bowel disease (IBD), such as Crohn’s disease.

Quick summary

["ASCA antibodies may indicate certain gut inflammation or autoimmune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
89532-6
Short code
ENA SS-A 52kD Ab CSF Ql Line blot
Synonyms
ENA SS-A 52kD Ab CSF Ql Line blot
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
line-blot
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like persistent diarrhea, abdominal pain, weight loss, or unexplained inflammation in your digestive tract. It can help distinguish between different types of IBD or other gastrointestinal conditions.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before your blood draw if instructed by your healthcare provider. Bring any medications you’re currently taking to your appointment.

How the Test Works

A small blood sample is taken from your arm. The blood is analyzed in a lab using an immunoassay method to detect specific antibodies against yeast proteins.

What the Results Mean

Positive results suggest a higher likelihood of conditions like Crohn’s disease, while negative results may rule out ASCA-related inflammation. Results alone don’t diagnose a condition—they’re used alongside other tests and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

ASCA antibodies are associated with certain subtypes of inflammatory bowel disease, particularly Crohn’s disease. Elevated levels may indicate chronic inflammation in the small intestine, helping guide treatment decisions or monitor disease activity.

Short name

ASCA Antibody Test

Frequently asked questions

What does a positive ASCA test mean for my health?
A positive result may raise suspicion for Crohn’s disease or other gut-related inflammation, but it’s not definitive. Your doctor will review the results alongside your medical history, symptoms, and other tests to make a diagnosis.
Can I eat or drink before my blood test?
Follow your doctor’s instructions, but generally, fasting for 8–12 hours before the draw is common. If unsure, ask your provider—some tests require fasting, while others do not.
How long will it take to get my results?
Results are typically available within 1–3 business days, depending on your lab and healthcare provider’s workflow. Your doctor will discuss them with you during a follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy