Serum or plasma concentration of total bilirubin

Why Is This Test Done?

Your doctor may order a total bilirubin test to check for liver problems, such as hepatitis, cirrhosis, or blockages in the bile ducts. It can also help diagnose conditions like Gilbert syndrome or monitor treatment for certain diseases. Sometimes, it’s used alongside other tests to evaluate jaundice, especially in newborns or adults with unexplained yellowing of the skin and eyes.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm, or in some cases, a urine sample may be collected for 24 hours to measure total bilirubin excretion. If you’re taking certain medications, let your doctor know, as they might affect results.

What the Results Mean

Higher than normal levels of bilirubin can indicate problems with liver function, bile flow, or red blood cell breakdown. Lower levels may suggest certain liver diseases or conditions affecting bilirubin metabolism. Your doctor will interpret results in the context of your overall health and other tests.

Common Conditions Linked to Bilirubin Levels

Elevated bilirubin is often linked to jaundice (yellowing of skin/eyes), liver diseases (like hepatitis or cirrhosis), bile duct obstructions, hemolytic anemia (rapid red blood cell destruction), or certain genetic disorders. Low levels may be associated with liver diseases that reduce bilirubin production or metabolism.