Skip to content

Serum or Plasma Substance Concentration (Qualitative) – Alpha-1 Antitrypsin Activity (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of alpha-1 antitrypsin, a protein that helps protect your lungs and liver from damage caused by enzymes released during inflammation.

Quick summary

["A1AT screening helps identify low levels that may increase your risk for lung diseases like emphysema or liver disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63411-3
Short code
ENA SS-a 60kD Ab Ser Ql IA
Synonyms
ENA SS-a 60kD Ab Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have a family history of lung diseases, liver problems, or if symptoms like chronic coughing, shortness of breath, or unexplained fatigue appear. It’s also used in monitoring conditions like chronic obstructive pulmonary disease (COPD) or alpha-1 antitrypsin deficiency.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re taking blood thinners, let your doctor know before the test.

What the Results Mean

Qualitative results indicate whether your A1AT activity is low (below normal) or within the expected range. Low levels may signal a genetic condition requiring further evaluation.

Common Conditions Linked to A1AT Levels

Low A1AT activity is strongly linked to alpha-1 antitrypsin deficiency, which can cause lung diseases (e.g., emphysema) or liver cirrhosis. Early screening can guide treatment decisions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin (A1AT) Activity Screening

Frequently asked questions

What causes alpha-1 antitrypsin deficiency?
Alpha-1 antitrypsin deficiency is typically caused by a genetic mutation passed down through families. It’s not usually caused by lifestyle factors like smoking or diet, though these can worsen lung disease symptoms in affected individuals.
How often should I get this test if I have a family history of A1AT deficiency?
If you have a family history, your doctor may recommend regular screening starting in your 20s or 30s, depending on your risk factors. Follow-up tests may be scheduled every few years or more frequently if symptoms arise.
Can diet or supplements help raise A1AT levels?
While no specific diet or supplement can raise A1AT levels, maintaining a balanced diet rich in antioxidants (e.g., vitamins C and E) and avoiding smoking may support lung health. Always consult your doctor before starting new supplements.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy