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Antibody to alpha-1 antitrypsin (serum/plasma) by immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against alpha-1 antitrypsin, a protein that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["Helps diagnose conditions linked to immune responses against alpha-1 antitrypsin."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63401-4
Short code
ENA SS-A Ab CSF IA-aCnc
Synonyms
ENA SS-A Ab CSF IA-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like chronic lung disease, liver issues, or unexplained inflammation. It can also be part of monitoring for autoimmune conditions or evaluating unusual immune responses.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Positive results indicate the presence of antibodies against alpha-1 antitrypsin, which may suggest an autoimmune reaction or other immune-mediated condition. The exact meaning depends on your symptoms and medical history.

Common Conditions Monitored

This test is sometimes used alongside alpha-1 antitrypsin levels to assess lung or liver risks in people with genetic alpha-1 antitrypsin deficiency or related conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin Antibody (IgG)

Frequently asked questions

What does a positive result mean?
A positive result means your immune system is producing antibodies against alpha-1 antitrypsin. This could be due to an autoimmune condition, infection, or another underlying issue. Your doctor will discuss next steps based on your symptoms and test results.
Can this test detect alpha-1 antitrypsin deficiency?
No, this test specifically measures antibodies, not the protein itself. Alpha-1 antitrypsin deficiency is typically diagnosed with separate blood tests for protein levels.
Does this test require fasting?
No fasting is required for this blood test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy