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Serum or Plasma Substance Concentration (Bromocresol Green Dye Binding) for Alpha-1 Antitrypsin

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung disease and liver problems by protecting tissues from harmful enzymes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63345-3
Short code
ENA SS-A Ab Fld Ql FC
Synonyms
ENA SS-A Ab Fld Ql FC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms of lung diseases (like emphysema or chronic bronchitis), liver problems, or if you have a family history of Alpha-1 Antitrypsin deficiency. It can also be part of a general health check or screening for genetic conditions.

What Does a Low Level Mean?

Low levels of Alpha-1 Antitrypsin may indicate a genetic deficiency, which can increase your risk of lung diseases or liver problems. High levels might be seen in certain liver diseases or during pregnancy.

What Happens During the Test?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it is analyzed using a dye-binding method (Bromocresol Green) to measure your Alpha-1 Antitrypsin concentration.

What Are Common Results?

Results are reported as a concentration value, but exact reference ranges can vary by lab. Your results will be compared to what is typical for healthy adults and any known conditions you may have.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin (Serum/Plasma) BCG

Frequently asked questions

What Are My Next Steps If My Test Results Are Abnormal?
If your Alpha-1 Antitrypsin level is low, your doctor may recommend genetic testing to confirm a deficiency. They may also discuss treatments, lifestyle changes, or monitoring for lung or liver issues, depending on your symptoms and family history.
How Often Should I Get This Test?
If you have a known Alpha-1 Antitrypsin deficiency, your doctor may recommend regular testing to monitor your levels and health. If this is a one-time screening, follow-up may not be needed unless you develop symptoms.
Can I Take Anything Special Before or After This Test?
No special preparations are needed for this blood test. Avoid alcohol for 24 hours before your appointment if possible, as it may affect liver enzyme levels indirectly. Rest assured that your blood sample is handled with care and privacy.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy