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Cerebrospinal Fluid (CSF) Protein by Immunoassay (TMB-based)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein levels in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Protein levels can help diagnose or monitor conditions affecting the central nervous system.

Quick summary

["Protein in CSF may indicate inflammation, infection, or other neurological issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109745-0
Short code
ENA SS-B Ab Msmt CSF
Synonyms
ENA SS-B Ab Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like severe headaches, neck stiffness, confusion, or neurological problems. It can also be used to diagnose conditions such as meningitis, multiple sclerosis, or brain tumors.

What to Expect Before the Test

You will likely have a lumbar puncture (spinal tap) to collect a small amount of CSF. This procedure involves inserting a needle into your lower back. You may feel pressure or discomfort, but it usually doesn’t cause pain. Rest for a few hours afterward.

What the Results Mean

Protein levels in CSF can vary widely. High protein levels may suggest inflammation, bleeding, or other issues affecting the brain or spinal cord. Low levels might be normal or could indicate certain neurological disorders. Your results will be interpreted by a healthcare provider based on your symptoms and medical history.

Common Conditions Affecting Results

Elevated protein levels in CSF are often seen in conditions like meningitis, multiple sclerosis, or brain tumors. Low protein levels may occur in certain genetic disorders or after certain treatments. Always discuss your results with your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein

Frequently asked questions

How long does it take to get my CSF protein results back?
Results are typically available within a few days to a week, depending on your lab and healthcare provider. Follow-up may be needed to discuss findings and next steps.
Can I eat or drink anything before this test?
You can eat and drink normally before the test, as it doesn’t require fasting. However, inform your doctor about any medications you’re taking, as they may affect the procedure.
Is there any risk or side effect from this test?
The most common side effect is mild headache or soreness at the injection site. Rarely, there may be bruising or infection. A healthcare provider can explain risks during your procedure.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy